The O'Brien Lab

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XXX Benkovic Building

Penn State University

University Park

Developing and applying Physical Bioinformatic techniques to measure rates of translation transcriptome-wide and their molecular origins as relates to fundamental biology and disease.

news

Mar 14, 2025 Protein accidentally lassos itself, helping explain unusual refolding behavior (Sci. Adv paper)
Feb 12, 2025 Congrats Dr. Ian Sitarik has successfully defended his thesis titled “Understanding the fundamental principles behind the influences of native and non-native entanglements on protein structure, function, and misfolding”
Nov 07, 2015 A long announcement with details

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selected publications